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Human Research Roadmap Gaps

Because the Human Research Program (HRP) is a risk-based program, all of the countermeasures and technologies we strive to develop are for the purpose of mitigating the highest risks to human health and performance. For each risk, HRP identifies gaps in knowledge about characterizing the risk and ability to mitigate the risk. Glenn Research Center’s role in the HRP is to research and develop closure to those gaps for which we have unique expertise. The following are the current gaps that GRC is addressing to help reduce the risks to acceptable levels or eliminate them all together.

Human Research Roadmap Gaps

Computational Modeling

CV1 Cardiovascular Impacts

CV2 Measuring VO2 inflight

CV8 Predicting Heart Disease

more…

Human Research Roadmap Gaps

Exploration Medical Capabilities

ExMC 4.02 Medical Imaging

ExMC 4.03 Back/Neck Injury

ExMC 4.04 Provide Oxygen to Crew

more…

Exploration Medical Capabilities

Gaps:

ExMC 4.02   Medical Imaging
ExMC 4.03   Back/Neck Injury
ExMC 4.04   Provide Oxygen to Crew
ExMC 4.06   Bone Fractures
ExMC 4.09   Medical Suction
ExMC 4.12   IV Fluids
ExMC 4.13   Renal Stones
ExMC 4.14   Medical Inventory

Human Research Roadmap Gaps

Human Health Countermeasures

ExMC 4.05 Measure Lab Analytes

ExMC 4.06 Bone Fractures

ExMC 4.08 Muscular Injuries

more…

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Cardiovascular Impacts

What are the in-flight alterations in cardiac structure and function?

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Measuring VO2 inflight

What is VO2max in-flight and immediately post-flight?

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Predicting Heart Disease

Can manifestations of sub-clinical or environmentally induced cardiovascular diseases during spaceflight be predicted?

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Outcome of Medical Events

We do not know the quantified health and mission outcomes due to medical events during exploration missions.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Doctor on Board?

We do not know how the inclusion of a physician crew medical officer quantitatively impacts medical risk during exploration missions.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Microgravity Countermeasures

How does 1/6-g and 3/8-g influence countermeasures?

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Efficient Exercise Regimen

Develop the most efficient exercise program for maintenance of muscle fitness.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Minimum Exercise Needed?

What is the minimum exercise regimen needed to maintain fitness levels for tasks?

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Exercise Hardware

Identify and validate exploration hardware for maintenance of muscle fitness.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Time Course of Changes in Muscle

Characterize the time course of changes in muscle protein turnover, muscle mass, and function during long duration space flight.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Bone Health Standard

A new acceptable bone health standard using an expanded surrogate for bone health needs to be defined for the flight environment.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Osteoporosis & Fractures

What is the incidence & prevalence of early onset osteoporosis or fragility fractures due to exposure to spaceflight.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Ocular changes

We do not know the etiological mechanisms and contributing risk factors for ocular structural and functional changes seen in-flight and post-flight.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Medical Imaging

We do not have the capability to provide non-invasive medical imaging during exploration missions.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Back/Neck Injury

Limited capability to treat back/neck pain and injuries in the space flight environment

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Provide Oxygen to Crew

We do not have the capability to deliver supplemental oxygen to crew members while minimizing local and cabin oxygen build-up during exploration missions.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Bone Fractures

We do not have the capability to stabilize bone fractures and accelerate fracture healing during exploration missions.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Medical Suction

We do not have the capability to provide medical suction and fluid containment during exploration missions.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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IV Fluids

We do not have the capability to generate and utilize sterile intravenous fluid from potable water during exploration missions.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Renal Stones

We have limited capability to screen for, diagnose, and treat renal stones during exploration missions.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Medical Inventory

We do not have the capability to track medical inventory in a manner that integrates securely with the medical system during exploration missions.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Measure Lab Analytes

We do not have the capability to measure laboratory analytes in a minimally invasive manner during exploration missions.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Bone Fractures

We do not have the capability to stabilize bone fractures and accelerate fracture healing during exploration missions.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Muscular Injuries

We do not have the capability to optimally treat musculoskeletal injuries during exploration missions.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Pharmacological Efficacy

We do not have the capability to package medications to preserve stability and shelf-life during exploration missions.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Immune Dysregulation

We have not defined and validated a terrestrial human analog for spaceflight-associated immune system dysregulation.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
X

Efficient Exercise Regimen

Develop the most efficient exercise program for maintenance of muscle fitness.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
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Minimum Exercise Needed?

What is the minimum exercise regimen needed to maintain fitness levels for tasks?

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.
X

Exercise Hardware

Identify and validate exploration hardware for maintenance of muscle fitness.

Evidence from medical records, spaceflight operations and research findings provides the basis for identifying the most significant human risks in space exploration, including physiological and performance effects from hazards such as altered gravity, radiation, hostile/closed environments, isolation and distance. Each risk is assigned to an HRP Element (divisions of human research) to identify knowledge gaps, or the critical questions that must be answered, in order to mitigate the risk. These gaps become the focus of research conducted to reduce the likelihood and consequence of risks becoming a reality. To learn more about the Risk Identification and Mitigation process and the tasks developed to reduce those risks for the program please click on the link below the gap for more information.